SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00161

Signal sequence   MGKLIFWLVFWLTIFWLGSA

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  GLP-1-Fc fusion protein: 4813.3ug/mL

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00161.cif

Structure  SPKB00161.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2429.00624

Aliphatic index  136.5

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  730.07

Aromaticity  0.3

Average rotatable bonds  3.65

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  25

X logP energy  3.9801

Hydropathy 



Literature Information


Title  Artificial synthetic signal peptide

DOI  NA,

Publication Year  2019

PubMed ID  NA,

Patent ID  CN110452288A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.