General Information
SPKB ID SPKB00159
Signal sequence MKSLILNIISVTLAITSTAASAPVESIFANQPDSSLTDTNDGVGVGMSTIKEEDFGKHFVENQILDEAVIMSLKLRKGVNLFFLDDIGLATELIGNKIAQIEAIDLSERLAQNWTNIRKNRLFGKREAEA
Length 130
Organism Komagataella phaffii
UniProt ID NA,
Motif 1..130
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency Increase exogenous protein 5 to 7 times
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB00159.cif
Physicochemical Information
Molecular weight 14221.26644
Aliphatic index 108.8461538
Isoelectric point 4.573460984
Charge (pH=7) -4.892160336
Topological polar surface area 5957.48
Aromaticity 0.053846154
Average rotatable bonds 3.776923077
Number of hydrogen bond donors 203
Number of hydrogen bond acceptors 197
X logP energy -59.76805
Hydropathy 
Literature Information
Title Optimized pichia pastoris GS115 mating pheromone alpha-factor signal peptide and application thereof
DOI NA,
Publication Year 2019
PubMed ID NA,
Patent ID CN110054667A,
