SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00157

Signal sequence   MKLSTILFTACATLALALAAPVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLEKREAEA

Length  89

Organism  Artificial

UniProt ID  NA,

Motif  1..89



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Enterokinase: 359400U/mL

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB00157.cif

Structure  SPKB00157.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  9291.45574

Aliphatic index  103.258427

Isoelectric point  3.746891645

Charge (pH=7)   -9.047967202

Topological polar surface area  3825.06

Aromaticity  0.056179775

Average rotatable bonds  3.426966292

Number of hydrogen bond donors  130

Number of hydrogen bond acceptors  132

X logP energy  -41.24043

Hydropathy 



Literature Information


Title  Method for increasing secretory expression level of enterokinase through improving signal peptide

DOI  NA,

Publication Year  2019

PubMed ID  NA,

Patent ID  CN110042068A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.