SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00156

Signal sequence   MKFSAVSIAAALASLVAAAPVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLEKREAEA

Length  88

Organism  Artificial

UniProt ID  NA,

Motif  1..88



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Enterokinase activity: 687,400U/mL

Type  Sec/SPI



Structure Information


PDB ID  7XOI,

Predicted Structure ID  SPKB00156.cif

Structure  SPKB00156.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  9060.10264

Aliphatic index  100

Isoelectric point  3.746894096

Charge (pH=7)   -8.985992486

Topological polar surface area  3775.73

Aromaticity  0.056818182

Average rotatable bonds  3.375

Number of hydrogen bond donors  127

Number of hydrogen bond acceptors  129

X logP energy  -42.59933

Hydropathy 



Literature Information


Title  Method for increasing secretory expression level of enterokinase through improving signal peptide

DOI  NA,

Publication Year  2019

PubMed ID  NA,

Patent ID  CN110042068A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.