SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00154

Signal sequence   MKFSTALLALAAVATAAPVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLEKREAEA

Length  86

Organism  Artificial

UniProt ID  NA,

Motif  1..86



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Enterokinase: 507000U/mL

Type  Sec/SPI



Structure Information


PDB ID  7XOI,

Predicted Structure ID  SPKB00154.cif

Structure  SPKB00154.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  8917.94504

Aliphatic index  97.79069767

Isoelectric point  3.746894096

Charge (pH=7)   -8.985992486

Topological polar surface area  3717.53

Aromaticity  0.058139535

Average rotatable bonds  3.395348837

Number of hydrogen bond donors  125

Number of hydrogen bond acceptors  127

X logP energy  -41.46783

Hydropathy 



Literature Information


Title  Method for increasing secretory expression level of enterokinase through improving signal peptide

DOI  NA,

Publication Year  2019

PubMed ID  NA,

Patent ID  CN110042068A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.