SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00151

Signal sequence   MKPLILSAILITLCITSIAVSAPVEGIFADLHDSSHPYITDDVGVRMSAIKEENPDRHFVGDEIPDEAVIQSFKSKRREILFLLDDIGSAVEFIGSNLAQIEANHLSERVQFSWTHIRKNQPFGKREAEA

Length  130

Organism  Komagataella pastoris?

UniProt ID  NA,

Motif  1..130



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00151.cif

Structure  SPKB00151.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  14514.51614

Aliphatic index  101.3076923

Isoelectric point  4.950668512

Charge (pH=7)   -6.588544051

Topological polar surface area  5947.72

Aromaticity  0.069230769

Average rotatable bonds  3.730769231

Number of hydrogen bond donors  204

Number of hydrogen bond acceptors  197

X logP energy  -54.58491

Hydropathy 



Literature Information


Title  Optimized Komagataella pastoris yeast alpha-factor signal peptide and application

DOI  NA,

Publication Year  2019

PubMed ID  NA,

Patent ID  CN110028562A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.