SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00129

Signal sequence   MLSILSALTLLGLSCA

Length  16

Organism  Komagataella phaffii

UniProt ID  C4QVL5,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00129.cif

Structure  SPKB00129.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1606.01164

Aliphatic index  183.125

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  580.74

Aromaticity  0

Average rotatable bonds  3.3125

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  23

X logP energy  -4.2952

Hydropathy 



Literature Information


Title  Endogenous signal peptides of Pichia pastoris and application thereof

DOI  NA,

Publication Year  2017

PubMed ID  NA,

Patent ID  CN106319638A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.